Tech Briefs

Briefs : Materials
Neuroprosthetics and Solutions for Restoring Sensorimotor Functions

Advances in body armor and life-saving technology have increased survival rates of severely injured military personnel. Unfortunately, the survivors of improvised explosive devices are often left with amputations and/or spinal cord injuries. The increase in amputations and...

Briefs : Medical
Implantable Microsystems for Anatomical Rewiring of Brain Circuitry

It has been demonstrated that after a stroke-like lesion in the cerebral cortex of non-human primates, the remaining intact tissue undergoes extensive neuro-physiological and neuroanatomical remodeling. The ability of cortical areas remote from the infarct to form new...

Briefs : Medical
Use of Recombinant Factor VIIa for Control of Combat-Related Hemorrhage

Blood loss is a major cause of death among combat casualties, accounting for nearly half of all deaths on the battlefield. The great majority of these deaths is due to intracavitary hemorrhage that cannot be controlled by traditional methods such as tourniquets or pressure...

Briefs : Materials
Biotic-Abiotic Interface Between the Body and an Artificial Limb

Because of its high mechanical properties, chemical stability, and biocompatibility, titanium is a commonly used material in dental and orthopedic applications. Its excellent biocompatibility allows titanium implants to be directly anchored to bone, or osseo-integrated. The...

Briefs : Medical
RF Device for Acquiring Images of the Human Body

A safe, non-invasive method for forming images through clothing of large groups of people, in order to search for concealed weapons either made of metal or not, has been developed. A millimeter wavelength scanner designed in a unique, ring-shaped configuration can obtain a full 360° image of the...

Briefs : Medical
Controlling Devices Using the Ear as an Output Source

Current methods of device control include joysticks, which involve using one or both hands, external microphones that are cumbersome and pick up ambient noise, and external arrays that are also cumbersome and can restrict a user’s movement. Additionally, the external microphone and array...

Briefs : Medical
Wireless Patient Monitoring Based on Personal Area Networks

The Wireless Patient Monitoring System deploys the Zigbee standard to create a Personal Area Network (a wireless network with a coverage area of around 10 m) that is capable of integrating into the same wireless network used by monitoring systems such as an electrocardiogram, pulse...

Briefs : Materials
Particle Distribution on Webs or Cloths

This technology provides a methodology and products that are formed from fibrous substrates or film-like surfaces by uniform impregnation with a particulate that is subsequently firmly attached. The extremely uniform distribution of the particulate is accomplished by 1) electrically charging a fibrous...

Briefs : Imaging
Apparatus for Cold, Pressurized Biogeochemical Experiments

A laboratory apparatus has been devised as a means of studying plausible biogeochemical reactions under high-pressure, low-temperature aqueous, anaerobic conditions like those conjectured to prevail in a liquid water ocean on Europa (the fourth largest moon of the planet Jupiter). The...

Briefs : Medical
Hollow Radiopaque Bioactive Microspheres Carry Drugs in Embolization Procedures

The number of applications of synthetic biomaterials continues to expand. However, the imaging of injected biomaterials is important to control the treatment procedure in real time, to avoid complications, and to assess therapeutic success. Embolization is the...

Briefs : Imaging
Isolation of Resistance-Bearing Microorganisms

Strategies were explored for inactivating resistance-bearing microorganisms, focusing on a new species (Bacillus horneckii sp. nov.) discovered on the surfaces of the Kennedy Space Center cleanroom facility in which the Phoenix lander was assembled. Two strains that belong to this novel species were...

Briefs : Medical
Growing B Lymphocytes in a Three-Dimensional Culture System

A three-dimensional (3D) culture system for growing long-lived B lymphocytes has been invented. The capabilities afforded by the system can be expected to expand the range of options for immunological research and related activities, including testing of immunogenicity of vaccine...

Briefs : Medical
Liquid Cooling/Warming Garment

The NASA liquid cooling/ventilating garment (LCVG) currently in use was developed over 40 years ago. With the commencement of a greater number of extra-vehicular activity (EVA) procedures with the construction of the International Space Station, problems of astronaut comfort, as well as the reduction of the...

Briefs : Medical
Tissuelike 3D Assemblies of Human Broncho-Epithelial Cells

Three-dimensional (3D) tissuelike assemblies (TLAs) of human bronchoepithelial (HBE) cells have been developed for use in in vitro research on infection of humans by respiratory viruses. The 2D monolayer HBE cell cultures heretofore used in such research lack the complex cell structures...

Briefs : Imaging
Oscillating Cell Culture Bioreactor

To better exploit the principles of gas transport and mass transport during the processes of cell seeding of 3D scaffolds and in vitro culture of 3D tissue engineered constructs, the oscillatory cell culture bioreactor provides a flow of cell suspensions and culture media directly through a porous 3D scaffold...

Briefs : Medical
Dual Optics/Ultrasound Imaging and Contrast Media for the Detection and Characterization of Prostate Cancer

Detection of prostate cancer has frequently been plagued with inadequate sensitivity and specificity. Hypoxia is the hallmark of malignancy because aggressive cancers outgrow their blood supply. Optical imaging is emerging as a physiologic...

Briefs : Photonics/Optics
Photochemical Tissue Bonding for Military Medical Applications

Joining severed vessels is a recurring problem in trauma and surgery. The basic technology of joining vessels using sutures has been available for centuries, but remains a slow and tedious process. A complete system for micro-anastomosis of vessels was developed that involves a laser...

Briefs : Medical
Magnetic Nanoparticles and Devices for Biomedical Uses

A program comprising several collaborative research efforts has been dedicated to advancing the art of utilization of magnetic nanoparticles for biomedical purposes. The research has been performed by three teams, each focusing on different aspects of the art:

Briefs : Medical
Endotracheal Intubation Device with Built-in Stylet and Colormetric Indicator

An endotracheal intubation device is utilized by doctors and paramedics to mechanically create an airway and to ventilate an injured person. The most common ventilating practice in the paramedic industry today requires assembly of a three-piece system at the time when...

Briefs : Medical
Edge Phantom Measures Sharpness of X-Ray Detectors

Digital radiography makes use of Xray detectors that yield a radiographic image of the object or patient between the X-ray source and the detector. Tools have been developed to assess the image quality characteristics of radiation images. One tool is an edge phantom, placed between source and...

Briefs : Medical
Paracellular Drug Delivery Through Baker’s Yeast Microcapsules

Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods. Since the oral mucosa is highly vascularised, drugs that are absorbed through the oral mucosa directly enter the systemic...

Briefs : Sensors/Data Acquisition
Vibrating Quartz Sensor Characterizes Liquid Samples

A novel analytical technology characterizes liquids for healthcare applications. As a drop of liquid evaporates on a vibrating quartz sensor, it undergoes distinctive phase changes representing the unique chemical and physical characteristics of the sample. This unique “fingerprint”...

Briefs : Medical
Reducing Field Distortion in Magnetic Resonance Imaging

A concept for a magnetic resonance imaging (MRI) system that would utilize a relatively weak magnetic field provides for several design features that differ significantly from the corresponding features of conventional MRI systems. Notable among these features are a magnetic- field...

Briefs : Medical
EPR Imaging at a Few Megahertz Using SQUID Detectors

An apparatus being developed for electron paramagnetic resonance (EPR) imaging operates in the resonance- frequency range of about 1 to 2 MHz — well below the microwave frequencies used in conventional EPR. Until now, in order to obtain sufficient signal-to-noise radios (SNRs) in...

Briefs : Medical
A Constant-Force Resistive Exercise Unit

A constant-force resistive exercise unit (CFREU) has been invented for use in both normal gravitational and microgravitational environments. In comparison with a typical conventional exercise machine, this CFREU weighs less and is less bulky: Whereas weight plates and associated bulky supporting...

Briefs : Sensors/Data Acquisition
Fluorogenic Cell-Based Biosensors for Monitoring Microbes

Fluorogenic cell-based sensor systems for detecting microbes (especially pathogenic ones) and some toxins and allergens are undergoing development. These systems harness the natural signal-transduction and amplification cascades that occur in mast cells upon activation with antigens....

Briefs : Medical
An Alternative Approach to Combination Vaccines

As the number of investigational and approved vaccines continues to increase, the frequency of vaccinations will soon reach a practical limit. The development of combination vaccines is a common practice that addresses the concern of repeated visits to the clinic by reducing the total number of...

Briefs : Medical
GUI To Facilitate Research on Biological Damage From Radiation

A graphical-user-interface (GUI) computer program has been developed to facilitate research on the damage caused by highly energetic particles and photons impinging on living organisms. The program brings together, into one computational workspace, computer codes that have been...

Briefs : Imaging
On-Demand Urine Analyzer

A lab-on-a-chip was developed that is capable of extracting biochemical indicators from urine samples and generating their surface-enhanced Raman spectra (SERS) so that the indicators can be quantified and identified. The development was motivated by the need to monitor and assess the effects of extended weightlessness,...

Briefs : Materials
Advanced Liquid-Cooling Garment Using Highly Thermally Conductive Sheets

This design of the liquid-cooling garment for NASA spacesuits allows the suit to remove metabolic heat from the human body more effectively, thereby increasing comfort and performance while reducing system mass. The garment is also more flexible, with fewer restrictions on...

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