Researchers combined mussel adhesive protein with decellularized extracellular matrix (dECM) to develop a composite hemostatic sponge that offers both strong tissue adhesion and biocompatible biodegradability.
When applied to a bleeding site, the sponge quickly absorbs blood and firmly adheres to tissues, enhancing hemostatic performance. Once hemostasis is achieved, the material naturally degrades and is absorbed in the body, while the exposed dECM supports tissue recovery. By activating the body’s intrinsic coagulation pathways, dECM helps accelerate blood clotting and promote wound stabilization.
In an anticoagulated liver injury model (warfarin-treated), the sponge adhered strongly to the injured tissue surface and demonstrated highly effective hemostatic performance. As a result, bleeding time was significantly reduced and blood loss markedly decreased. Compared to conventional hemostatic materials, the sponge also induced less inflammation and tissue damage, while promoting enhanced wound stabilization during the early stages of healing. (Image credit: Postech)
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