Fast-dissolving microneedle patch enables minimally invasive and local delivery of biodegradable microparticles as distributive depots for sustained release of therapeutics in diseased tissues. (Credit: Shanghai Jiao Tong University Journal Center)

A team searched for small molecules as drug candidates and identified a bifunctional antibiotic, azithromycin (AZM), that not only inhibits bacterial growth but also modulates immune cells to suppress inflammation. They further engineered a dissolvable microneedle patch loaded with biodegradable microparticles for local and painless delivery of AZM to the gingival tissues.

Inflammatory cytokines were decreased while anti-inflammatory cytokines and M2 macrophage were increased with AZM treatments in vitro. In vivo delivery of the AZM-loaded microneedle patch demonstrated the same effects on cytokine secretion and the promotion of tissue healing and bone regeneration. In addition, microparticles containing anti-inflammatory interleukin-4 alone or in combination with separately formulated AZM microparticles, had similar or slightly enhanced therapeutic outcomes respectively.

The dual action of AZM in suppressing bacterial growth and modulating immune responses demonstrates its potential as a comprehensive therapeutic strategy for periodontitis. These findings provide a basis for further research and potentially pave the way for the development of novel and effective treatment options for this prevalent oral disease and more chronic inflammatory diseases.

Source 

Topics:
Drug Delivery Medical Smart Patches and Bandages

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