Inspired by the structure of electron-transfer chains in the mitochondria, a research group has developed a 3D mesoporous biosensing-membrane with neighborhood nanostructures that shows excellent sensitivity and long-term stability.

In preparing the biosensing-membranes, the researchers used tannic acid-3-aminopropyltriethoxysilane-Fe3+ (TA-APT-ES-Fe) ternary coating to properly assemble and adjacently confine Prussian blue (PB) and GOx in the 3D mesoporous carbon nanotube (CNT) membrane electrode.

The spatially confined microenvironment stabilizes PB and GOx. The separation function of the CNT membrane further intensifies the sensing stability by in-situ removal of interferents from the analytes. The as-prepared mesoporous biosensing-membrane exhibits good sensitivity and long-term stability with a negligible response drift for up to eight hours, thus outperforming the reported results. (Image credit: Zhang Hao)

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