Researchers at North Carolina State University, Raleigh, have embedded needle-like carbon nanofibers into an elastic silicone membrane, creating a flexible “bed of nails” that may open the door to the development of new drug-delivery systems, they say.
Scientists are interested in discovering new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes coated with a relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon’s surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn.
In order to test this concept, they first needed to develop an elastic material impregnated with aligned, nanoscale needles.
The researchers first “grew” the nanofibers on an aluminum bed, or substrate. They then added a drop of liquid silicone polymer. The polymer, nanofibers, and substrate were then spun, so that centrifugal force spread the liquid polymer in a thin layer between the nanofibers and allowing the fibers to stick out above the surface. The polymer was then cured, turning the liquid polymer into a solid, elastic membrane. Researchers then dissolved the aluminum substrate, leaving the membrane embedded with the carbon nanofibers “needles.”
The research was supported by the National Science Foundation and the Department of Defense, Defense Threat Reduction Agency.
