In an advance for medical imaging, scientists from University of North Carolina Lineberger Comprehensive Cancer Center have discovered a method for creating radioactive tracers to better track pharmaceuticals in the body as well as image diseases, such as cancer, and other medical conditions.

The researchers reported a method for creating tracers used with positron emission tomography, or PET, imaging. Researchers said their findings could make it possible to attach radioactive tags to compounds that previously have been difficult or even impossible to label.

"Positron emission tomography is a powerful and rapidly developing technology that plays key roles in medical imaging as well as in drug discovery and development," said the study's co-corresponding author, UNC Lineberger's Zibo Li, Ph.D., an associate professor in the UNC School of Medicine Department of Radiology, and director of the Cyclotron and Radiochemistry Program at the UNC Biomedical Research Imaging Center. "This discovery opens a new window for generating novel PET agents from existing drugs."

PET scans track a radioactive tag that is attached to a compound. These tracers are generally injected into the body, and they produce bright images on medical scans as the tracer accumulates in the targeted lesion, organ, or tissue. Scientists can attach tags to molecules like glucose, which will accumulate in tumors as cancer cells consume sugar to drive their overactive growth, or to amino acids, which, as the building blocks of proteins, can be highly consumed in tumors. They can also attach them to potential new drugs to track their course in the body.

"What is believed to occur is that tumor molecules uptake these resources faster than healthy cells do," said David Nicewicz, Ph.D., professor in the UNC-Chapel Hill Department of Chemistry and the co-corresponding author of the study. "What we've contributed to the field is a new method to introduce radio-labeled isotopes of atoms into drug molecules in a way that hasn't been done before."

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