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Tohid Didar, the McMaster mechanical and biomedical engineer who led the research team. (Credit: McMaster University)

A new coating prevents clotting and infection in synthetic vascular grafts, while also accelerating the body’s own process for integrating the grafted vessels. Variants of the coating material are “smart” coatings that line the vessels and prevent clot formation and bacterial adhesion while selectively attracting targeted cells that foster the growth of natural vessel walls, promoting faster, smoother healing.

Each article verifies the success of a different formulation of the coating, one designed for Dacron grafts (Small), the other for Teflon grafts (ACS Science) – the two major materials used to make artificial vessels. The smart materials are made to coat the inner walls of new sections of replacement vessels typically deployed after injury or disease.

The components used in the material have already been approved for use in humans, which is expected to shorten the process for getting the new material approved for use in clinical settings.

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