Amputees often experience the sensation of a “phantom limb”—a feeling that a missing body part is still there. That sensory illusion is closer to becoming a reality thanks to a team of engineers at Johns Hopkins University that have created an electronic skin. When layered on top of prosthetic hands, this e-dermis brings back a real sense of touch through the fingertips.
“After many years, I felt my hand, as if a hollow shell got filled with life again,” says the amputee who served as the team's principal volunteer. (The research protocol used in the study does not allow identification of the amputee volunteers.)
Made of fabric and rubber laced with sensors to mimic nerve endings, e-dermis recreates a sense of touch as well as pain by sensing stimuli and relaying the impulses back to the peripheral nerves.
“We've made a sensor that goes over the fingertips of a prosthetic hand and acts like your own skin would,” says Luke Osborn, a graduate student in biomedical engineering. “It's inspired by what is happening in human biology, with receptors for both touch and pain.
“This is interesting and new,” Osborn adds, “because now we can have a prosthetic hand that is already on the market and fit it with an e-dermis that can tell the wearer whether he or she is picking up something that is round or whether it has sharp points.”
The work, published online in the journal Science Robotics, shows it's possible to restore a range of natural, touch-based feelings to amputees who use prosthetic limbs. The ability to detect pain could be useful, for instance, not only in prosthetic hands but also in lower limb prostheses, alerting the user to potential damage to the device.
Human skin is made up of a complex network of receptors that relay a variety of sensations to the brain. This network provided a biological template for the research team, which includes members from the Johns Hopkins departments of biomedical engineering, electrical and computer engineering, and neurology, and from the Singapore Institute of Neurotechnology.
Bringing a more human touch to modern prosthetic designs is critical, especially when it comes to incorporating the ability to feel pain, Osborn says.
“Pain is, of course, unpleasant, but it's also an essential, protective sense of touch that is lacking in the prostheses that are currently available to amputees,” he says. “Advances in prosthesis designs and control mechanisms can aid an amputee's ability to regain lost function, but they often lack meaningful, tactile feedback or perception.”
That's where the e-dermis comes in, conveying information to the amputee by stimulating peripheral nerves in the arm, making the so-called phantom limb come to life. Inspired by human biology, the e-dermis enables its user to sense a continuous spectrum of tactile perceptions, from light touch to noxious or painful stimulus.
The e-dermis does this by electrically stimulating the amputee's nerves in a noninvasive way, through the skin, says the paper's senior author, Nitish Thakor, a professor of biomedical engineering and director of the Biomedical Instrumentation and Neuroengineering Laboratory at Johns Hopkins.
“For the first time, a prosthesis can provide a range of perceptions from fine touch to noxious to an amputee, making it more like a human hand,” says Thakor, co-founder of Infinite Biomedical Technologies, the Baltimore-based company that provided the prosthetic hardware used in the study.
The team created a “neuromorphic model” mimicking the touch and pain receptors of the human nervous system, allowing the e-dermis to electronically encode sensations just as the receptors in the skin would. Tracking brain activity via electroencephalography, or EEG, the team determined that the test subject was able to perceive these sensations in his phantom hand.
The researchers then connected the e-dermis output to the volunteer by using a noninvasive method known as transcutaneous electrical nerve stimulation, or TENS. In a pain-detection task, the team determined that the test subject and the prosthesis were able to experience a natural, reflexive reaction to both pain while touching a pointed object and non-pain when touching a round object.
The e-dermis is not sensitive to temperature — for this study, the team focused on detecting object curvature (for touch and shape perception) and sharpness (for pain perception). The e-dermis technology could be used to make robotic systems more human, and it could also be used to expand or extend to astronaut gloves and space suits, Osborn says.
The researchers plan to further develop the technology and work to better understand how to provide meaningful sensory information to amputees in the hopes of making the system ready for widespread patient use.
Johns Hopkins is a pioneer in the field of upper limb dexterous prosthesis. More than a decade ago, the university's Applied Physics Laboratory led the development of the advanced Modular Prosthetic Limb, which an amputee patient controls with the muscles and nerves that once controlled his or her real arm or hand.
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