The Voltaglue glue patch can be guided through the body to where the tear is located. (Credit: NTU Singapore)

A team of researchers has developed a device that offers a quicker and less-invasive way to seal tears and holes in blood vessels, using an electrically activated glue patch applied via a minimally invasive balloon catheter.

This device could eventually replace the need for open or keyhole surgery to patch up or stitch together internal blood vessel defects. After inserting the catheter into an appropriate blood vessel, the glue patch — nicknamed Voltaglue — can be guided through the body to where the tear is located and then activated using retractable electrodes to glue it shut in a few minutes, all without making a single surgical cut.

The adhesive works in wet environments and hardens when a voltage is applied to it. This catheter device is the first proof-of-concept application of Voltaglue in a medical setting. The team showed in lab experiments on a pig’s heart that the patch can be safely and effectively administered in a variety of situations, including withstanding the high pulsatile pressure of blood in arteries like the aorta.

The flexible catheter is first inserted and guided through the blood vessel. Once at the site of the break, the balloon is expanded so that the injury is covered by the Voltaglue patch. The patch starts to set after 20 seconds and fully hardens between 3 to 5 minutes. Upon hardening, the patch effectively glues the broken vessel together, thereby sealing the two broken ends shut.