ImecAntwerp, Belgium

A prototype implantable chip aims to give patients more intuitive control over their arm prosthetics. The thin-silicon chip is a world’s first for electrode density and was developed by Imec, a research and innovation hub that focuses on nano-electronics and digital technology, in collaboration with researchers at the University of Florida. It was fabricated as part of the IMPRESS project funded by the DARPA’s HAPTIX program to create a closed-loop system for future-generation haptic prosthetics technology.

The implantable chip aims to give patients more intuitive control over their arm prosthetics. (Credit: Imec)

Existing arm prosthetics technologies have been shown to give patients the ability to move their artificial arm and hand to grasp and manipulate objects. This is done by reading out signals from the person’s muscles or peripheral nerves to control electromotors in the prosthesis, thereby conveying intent. Although very helpful, these prosthetics still don’t allow fine motor control and don’t give patients a feeling of touch. Future advanced prosthetics under development will provide amputees with rich sensory content from these artificial limbs by delivering precise electrical patterns to the person’s peripheral nerves using implanted electrode interfaces.

According to Rizwan Bashirullah, associate professor of electrical and computer engineering and director of the University of Florida’s IMPRESS program (Implantable Multimodal Peripheral Recording and Stimulation System), “This effort aims to create new peripheral nerve interfaces with greater channel count, electrode density, and information stability, enabled largely by Imec’s technological innovation.”

As part of IMPRESS, Imec has now made a prototype ultrathin (35 μm) chip with a biocompatible, hermetic, and flexible packaging. On its surface are 64 electrodes, with a possible extension to 128. This exceptionally high number of electrodes allows fine-grained stimulation and recording. Through a needle attached to the chip, the package can be inserted and attached inside a nerve bundle, further increasing the precision of reading and stimulation compared with current technology, which has substantially fewer electrodes and is wrapped around the nerve bundle. In practice, this chip will strive to give patients more control over their prosthetic arm and hand, and also the possibility of a finer haptic feedback.

This research creates new peripheral nerve interfaces with greater channel count, electrode density, and information stability. (Credit: Imec)

“Our expertise in silicon neuro-interfaces made Imec a natural fit for this project, where we have reached an important milestone for future-generation haptic prosthetics,” says Dries Braeken, R&D manager and project manager of IMPRESS at Imec. “These interfaces allow a much higher density of electrodes and greater flexibility in recording and stimulating than any other technology. With the completion of this prototype and the first phase of the project, we look forward to the next phase where we will make the prototype ready for long-term implanted testing.”

“A new biocompatible chip encapsulation technology is used, based on the stacking of nanolayers with superior diffusion barrier properties, alternating with very thin polymer layers with excellent mechanical behavior,” explains Maaike Op de Beeck, program manager at Imec. “The final result is an ultrathin flexible electronic device with a thickness comparable to that of a human hair, hence ultimately suitable for minimally invasive implantation.”

This work was sponsored by the Defense Advanced Research Projects Agency’s (DARPA) Biological Technologies Office under the auspices of Dr. Doug Weber through the Space and Naval Warfare Systems Center, Pacific Grant/Contract No. N66001-15-C-4018 to the University of Florida. A video of the technology is available at here .

Medical Design Briefs Magazine

This article first appeared in the July, 2017 issue of Medical Design Briefs Magazine.

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