A soft, thread-like implantable bioelectronic device is designed to sense and stimulate tissues with minimal invasiveness. Roughly a quarter of a millimeter in diameter, the NeuroString fiber can incorporate hundreds to thousands of independent electronic channels capable of detecting neurochemicals, monitoring muscle contractions, recording single-neuron activity, or delivering targeted stimulation.
The device is engineered for exceptional flexibility and biocompatibility, allowing it to remain in the body for months with reduced risk of discomfort or damage. A roll-up fabrication method spirals ultra-thin circuitry into a compact fiber, exposing sensors on the surface while routing individual connection lines internally. Researchers have demonstrated versions containing up to 1,280 channels, with potential for even higher densities.
In preclinical studies, the device monitored intestinal activity in pigs and recorded neuronal signals in mice over extended periods. The platform could support applications ranging from gastrointestinal diagnostics and closed-loop neural stimulation to precision drug delivery. Its tubular design may enable integrated sensing-and-delivery systems, while future adaptations could advance wearable electronics and soft robotic technologies. (Credit: Bao Lab/Stanford)
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