An ingestible x-ray dosimeter detects radiation dose in real time. Combining the novel capsule design and a neural network-based regression model that calculates radiation dose from the information captured by the capsule, researchers found that they could provide approximately five times more accurate monitoring of the dose delivered than current standard methods.
The capsule can measure the dose of radiation and physiological changes in pH and temperature in real time during gastrointestinal radiotherapy. Key components of the capsule include a flexible optical fiber encapsulated with nanoscintillators that illuminate in the presence of radiation, a pH-responsive film, a fluidic module with multiple inlets for dynamic gastric fluid sampling, two sensors for dose and pH measurements, a microcontroller circuit board that processes photoelectric signals to be transmitted to a mobile application, and a button-sized silver oxide battery powering the capsule.
When the capsule is ingested and reaches the gastrointestinal tract, the nanoscintillators exhibit heightened luminescence in the presence of increased x-ray radiation. A sensor within the capsule measures the glow from the nanoscintillators to determine the radiation delivered to the targeted area. The fluidic module allows gastric fluid to be collected for pH detection. (Image credit: National University of Singapore)
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