Scientists have developed a nanobiosensor based on gold nanowires. Originally only intended for the detection of COVID-19-associated antigens and antibodies, the biosensor is also transferable to other biomarkers.

The researchers’ aim was to develop sensor systems that can also be used for detecting low virus loads while providing quick and accurate results. They used nanowires made of gold, which can be employed to detect various biomolecules such as enzymes, proteins, and antibodies. This approach was combined with electrochemical impedance spectroscopy, a technique that provides information on various processes at the electrode-electrolyte interface, including charge transfer, diffusion transport, and formation of an electrical double layer, as well as on the properties of the measurement system. This includes solution resistance and roughness or porosity of the electrode surface.

The nanoscopic biosensor chip consists of six pairs of interlocking gold nanowire devices for detecting SARS-CoV-2 antigens and antibodies. (Image credit: HZDR/Sandoval Bojorquez)

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