Various human implantable medical devices have been developed in recent years for use in the clinical field. These devices include brain–machine interfaces, in which a chip is implanted into the brain to enable humans to move machines using only their thoughts, and deep brain stimulators for treating Parkinson’s disease and other brain diseases.

However, devices implanted into the human body may elicit an immune response from surrounding tissues, and the resulting performance degradation makes it difficult to use these devices for a long period. When a deep brain stimulator or chip is implanted into the brain, the device may not operate stably, and its lifespan may be reduced owing to the actions of brain immune cells such as microglia. This would require an additional operation to replace the device.

The Korea Institute of Science and Technology (KIST) announced a joint research effort by the research team at the Brain Science Institute, led by Dr. Il-Joo Cho, and the research team at Yonsei University, led by Dr. Jung-Mok Seo, for developing a coating technology for medical devices implanted into the human body, including the brain. This technology was able to minimize tissue damage during the implantation process and inhibit the inflammatory response. In addition, the lifespan of coated devices was more than four times that of existing devices.

The developed technology involves a method for creating a thin and uniform coating of a monolayer and lubricating oil on the surface of the implantable devices. Such a coating minimizes tissue damage by reducing the friction between a device and tissues, which is generated when the device is implanted into the human body. In addition, coated devices exhibit the anti-bioadhesion property, i.e., the prevention of the adhesion of immune cells activated by the immune rejection response to the device surface.

Top-to-bottom exploded view of LIPS applied to a neural probe and schematic of the LIPS fabrication process. (Credit: Korea Institute of Science and Technology)

The research team developed a lubricant-coated neural probe with 32 electrodes for measuring brain signals, and they showed the reduction of immune responses through in-vivo experiments. This probe was coated by employing the developed technology and implanted into the rodent brain. Brain signals were successfully observed from over 90 percent of the electrodes immediately after implantation. The number of signals was twice that obtained using uncoated neural probes. Furthermore, the observation of brain tissues confirmed that the tissue damage that generally occurs during implantation was minimized. The signal amplitude of uncoated probes reduced over time owing to the adhesion of immune cells to the probe surface. In contrast, the coated probe exhibited the anti-bioadhesion property. It stably measured brain signals for four months, which was four times the lifespan of uncoated probes. Dr. Cho and Dr. Seo stated that “the developed coating technology can be applied to human implantable devices for not only the brain, but also other parts of the body, and the technology can significantly extend the lifespan of such devices.” Moreover, they mentioned that “this technology is also expected to contribute to faster commercialization by considerably extending the replacement cycle of human implantable medical devices.”

The research was backed by the Ministry of Science and ICT under the National Research Foundation of Korea’s Young Researcher Program and Original Technology Research Program for Brain Science. The findings in this study were published in Advanced Science. 1

Reference

  1. Lee, Y., Shin, H., Lee, D., Choi, S., Cho, I.-J., Seo, J., A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording. Adv. Sci. 2021, 8, 2100231.

For more information, visit here .



Magazine cover
Medical Design Briefs Magazine

This article first appeared in the November, 2021 issue of Medical Design Briefs Magazine.

Read more articles from this issue here.

Read more articles from the archives here.