Inspection Equipment

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This system eliminates the need for manual inspections using microscopes.

A system was devised to aid in the inspection of micro-electrode assemblies utilized in clinical lab instruments to conduct impedance measurements on living cells in a 384 bottomless well casing with the electrode layer bonded to the housing, creating the closed-cell, real-time data acquisition instrument for assay tests.

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Since the earliest missions in space, NASA specialists have performed experiments in low gravity. Protein crystal growth, cell and tissue cultures, and separation technologies such as electrophoresis and magnetophoresis have been studied.
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Bacteria are grown under conditions imitating those at ocean depths.

A laboratory apparatus has been devised as a means of studying plausible biogeochemical reactions under high-pressure, low-temperature aqueous, anaerobic conditions like those conjectured to prevail in a liquid water ocean on Europa (the fourth largest moon of the planet Jupiter). The experiments to be performed by use of this apparatus are intended to enhance understanding of how life (if any) could originate and evolve in the Europa ocean environment. Inasmuch as terrestrial barophilic, psychrophilic organisms that thrive under anaerobic conditions are used in the experiments, the experiments may also contribute to terrestrial biogeochemistry.
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Strategies were explored for inactivating resistance-bearing microorganisms, focusing on a new species (Bacillus horneckii sp. nov.) discovered on the surfaces of the Kennedy Space Center cleanroom facility in which the Phoenix lander was assembled. Two strains that belong to this novel species were isolated and subjected to a comprehensive, polyphasic analysis to characterize their taxonomic position.
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Cells grown in this system live long and closely resemble in vivo cells.

A three-dimensional (3D) culture system for growing long-lived B lymphocytes has been invented. The capabilities afforded by the system can be expected to expand the range of options for immunological research and related activities, including testing of immunogenicity of vaccine candidates in vitro, generation of human monoclonal antibodies, and immunotherapy.

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This bioreactor is well suited to work with different biological specimens.

To better exploit the principles of gas transport and mass transport during the processes of cell seeding of 3D scaffolds and in vitro culture of 3D tissue engineered constructs, the oscillatory cell culture bioreactor provides a flow of cell suspensions and culture media directly through a porous 3D scaffold (during cell seeding) and a 3D construct (during subsequent cultivation) within a highly gas-permeable closed-loop tube. This design is simple, modular, and flexible, and its component parts are easy to assemble and operate, and are inexpensive. Chamber volume can be very low, but can be easily scaled up. This innovation is well suited to work with different biological specimens, particularly with cells having high oxygen requirements and/or shear sensitivity, and different scaffold structures and dimensions.
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Transgenomic (Omaha, NE) has introduced the SURVEY-OR Scan K-RAS kit, a mutation detection kit that features the SURVEYOR Nuclease and WAVE® HS DHPLC platform. It uses PCR amplification reaction and hybridization to form heteroduplex DNA molecules in samples with K-RAS mutation. K-RAS mutation status is a strong predictor of resitstance to cancer treatment. The kit detects mutations by enzymatic cleavage at mutation sites, and identifies all known and unknown mutations in both K-RAS coding exons. It also includes control templates for common mutation sites (codons 12, 13, and 61), and offers high analytic sensitivity, detecting 1% of K-RAS mutant in a background of wild-type genomic DNA. It can be applied to formalin-fixed paraffin-embedded tissues.

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