Drug Delivery & Dispensing

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This method can be performed on multiple devices simultaneously or one at a time as quality control.

A variety of silicon-fabricated devices is used in medical applications such as drug and cell delivery, and DNA and protein separation and analysis. In applications such as drug delivery from implantable devices, the silicon device structure must have superior precision. In particular, the nano-channel size in implantable drug delivery membranes strongly determines the drug release from the implanted reservoir. An accidental difference in the nano size may translate into ineffective medical treatment or dangerous overdosing.
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Promising news for millions of Americans living with type 1 diabetes: The FDA has issued guidelines specific to developing an artificial pancreas — a system that would serve to continuously monitor blood glucose levels and deliver the correct amount of insulin to the body when needed, functioning just like a normal pancreas. 
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Among other advantages, a new resin offers an attractive option for manufacturers seeking to move toward animal-derivative-free materials.

Material selection plays an important role in the design of a medical device or bioprocessing system. It can improve end-user satisfaction, product reliability, and manufacturability of the device, as well as simplify the 510(k) application process. Various certifications such as animal-derivative-free, USP Class VI, and ISO 10993-5 are just a few of those desired by medical device manufacturers and biopharmaceutical companies. As a result, Value Plastics, a Nordson company, has chosen to mold a large variety of its connectors with a new polypropylene resin in order to better fulfill customer needs and expectations. This material, manufactured by Flint Hills Resources, is represented by part numbers ending in “-6005.” This technical brief will explain the multiple benefits to manufacturers who incorporate this resin into their end products.

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A recent patient study from Cambridge Consultants indicates user experience and satisfaction are particularly important in the success of drug delivery and combination devices. Furthermore, investing time and effort into increasing the ease-of-use of these devices can pay off — 77% of patients in the study said they would be willing to pay slightly more (around $5) for more user-friendly devices.
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Valveless design and sapphire-hard internals provide drift-free accuracy without recalibration for millions of maintenance-free dispenses.

From R&D in the laboratory to production process control, from disposable component assembly to OEM diagnostic instrumentation, a broad array of medical and medical support applications rely on precise dispensing or metering of fluids. But just as diverse as the applications are the varieties of fluids, their chemical and physical characteristics, and the specific application parameters. It could then be concluded that fluid control components, including pumps, need to have the flexibility to handle many different fluids and applications.

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Recalls for medical devices are at an all-time high, and defective software is one of the top causes. FDA data indicate that one in every three medical devices that makes use of software for its operation has been recalled due to failure in the software itself.

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Watson-Marlow Pumps Group (Wilmington, MA) offers the 114D pumphead, suitable for multiple individual pumphead installations. The single channel 114 measures 64 × 64 × 41 mm. It features four rollers for reduced pulsation, and spring loaded tube holders with automatic tube stretching for high accuracy and repeatable flow and pressure performance. Tubing can be loaded easily using one hand, in a matter of seconds.
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