Biosensors

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The SHT21 digital humidity and temperature sensor from Sensirion (Westlake Village, CA) is encapsulated in a 3 × 3 × 1.1 mm DFN 3-0 package. Over-molding provides protection against harsh environments. It is fully calibrated and provides an I²C digital interface. Analog output modes are available upon request. Typical sensor accuracy is ±2% RH over 20-80% RH and ±0.3°C over 25 to 42 °C. Provided on tape and reel, the reflow-solderable SHT21 is suitable for high-volume applications.
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Key analytes can be detected using sample volumes of only 100 mL.

An apparatus that includes highly miniaturized thin-film electrochemical sensor array has been demonstrated as a prototype of instruments for simultaneous detection of multiple substances of interest (analytes) and measurement of acidity or alkalinity in bioprocess streams. Measurements of pH and of concentrations of nutrients and wastes in cell-culture media, made by use of these instruments, are to be used as feedback for optimizing the growth of cells or the production of desired substances by the cultured cells. The apparatus is designed to utilize samples of minimal volume so as to minimize any perturbation of monitored processes.

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The field of biosensors may be getting a boost from an unlikely source: coffee rings. UCLA researchers are studying the "coffee ring" phenomenon - the observation that many liquids, when spilled, evaporate to leave a darker ring around the perimeter that contains a much higher concentration of particles than the center. A better understanding of how these rings behave at the micro- and nano-scale would help provide guidance for the development of more advanced biosensors.
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OPTEK Technology (Carrollton, TX) offers the OCB350 Series fluid sensor that features automatic calibration circuitry. It is available with multiple output states for medical applications. Designers can initiate the calibration procedure at any time by grounding the J1-pin-4, which allows the device to be remotely calibrated and then mounted in the equipment. The housing includes an opening that accommodates clear tubing with outer diameters of 0.0625”, 0.125”, or 0.1875”. The infrared LED features a forward DC current of 50 mA with a peak current of 1.0 A. Reverse DC voltage is 2.0 V and power dissipation is 100 mW. The output photo-transistor features a maximum collector-emitter volage of 24V or 30V, with collector DC current of 50 mA and power dissipation to 100 mW. Operating temperature ranges from -40 °C to 85 °C.

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Potential applications include detecting selected biomolecules and treating some brain injuries.

A program comprising several collaborative research efforts has been dedicated to advancing the art of utilization of magnetic nanoparticles for biomedical purposes. The research has been performed by three teams, each focusing on different aspects of the art:
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The Model CR rod and cylinder sensor from MTS Systems Corp., Sensors Division (Cary, NC), integrates a standard Model CS or CM sensor inside a rugged, thick steel mechanical package that protects the electronics from mechanical and environmental damage. It employs magnetostrictive, non-contact, absolute position sensing technology modules, and is rated to withstand shock and vibration up to 5 g. Applications include gurneys, hospital beds, wheelchair lifts, and dental chairs.

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University of Florida engineers have designed and tested versions of a sensor that can diagnose and treat a variety of diseases, for example, by monitoring diabetics' glucose levels via their breath or detecting possible indicators of breast cancer in saliva. The sensor can be mass-produced inexpensively with technology currently used for making chips in cell phones.
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